
1. »ØÊ×°²½ø×¨Àû
רÀûÕù¶ËÉæ¼°PCSK9Á¬Ïµ±íλµÄ±£»¤¶ø·Ç¹Å°åµÄ¿¹Ìå½á¹¹
ÎôʱAmgenÔÚ×öPCSK9µÄ¿¹Ìåʱ¼ä£¬ÓÃÁËÈ«³¤µÄÂѰ×È¥ÃâÒßСÊó»òÕßÈ¥¿¹Ìå¿âɸѡ¿¹Ì壬ͨ¹ý¹¦Ð§ÐÔɸѡµ½ÁËһЩÖкͻîÐÔµ¥¿¹¡£È»ºó£¬½«ÕâЩ¹¦Ð§ÐÔµ¥¿¹µÄʶ±ðλµã£¬Í¨¹ý¹²½á¾§¸øÕÒÁ˳öÀ´£¬×îºóÉêÇëÁ˹¦Ð§ÐÔ±íλ°±»ùËáµÄרÀû¡£
2. ¿¹ÌåרÀûÊÇ´óʶù£¬±£»¤¡¢Í»ÆÆÒªË«¹ÜÆëÏÂ
רÀûÔÚ¿¹ÌåÁìÓòÕ¼ÓкÜÖ÷ÒªµÄְ룬ÒÔÍù£¬¿¹ÌåµÄרÀûÖ÷񻃾¼°µ½Æä½á¹¹ÐòÁм°°ÐÔÁ¬ÏµÎ»µãµÄ±£»¤£¬
°²½øµÄרÀûÔòÍØÕ¹ÖÁ±íλµÄ±£»¤£¬ÑÓÉìÁËרÀû±£»¤¹æÄ££¬¸øØÊºóÕßÖÆÔìÁËרÀûÕϰ¡£ÕâÑùÒÔÀ´£¬Î´À´µÄ¿¹ÌåÐÂÒ©Ñз¢ÕßÊÆ±ØÔÚ¿¹ÌåµÄרÀû±£»¤·½ÃæÏò¾ÞÍ·¹«Ë¾ÃÇ¿´Æë£¬Í¬Ê±×¨ÀûµÄÍ»ÆÆÒ²»á±»ÈÕ½¥ÖØÊÓ¡£
¿¹ÌåרÀû±£»¤

¡øÉϺ£°¶ÂõÉúÎï¿Æ¼¼ÓÐÏÞ¹«Ë¾×ܲÃÎâ³½±ù²©Ê¿
ȪԴ£º2016Äê11ÔÂ24 ÈÕ×ðÁú¿Ê±ËÕÖÝÉúÎï´ó·Ö×ÓÒ©ÎïÑз¢Ç°ÑØÊÖÒÕ×êÑлá
Îâ³½±ù²©Ê¿ÌåÏÖ£¬´Ó¿¹ÌåµÄÉú³¤½Ç¶ÈÀ´Ëµ£¬Îª¹æ±Ü¿¹ÌåרÀû³åÍ»ÎÊÌâ£¬×·ËæÏȽø¿¹ÌåµÄ¿ª·¢Õ½ÂԵĿÉÐÐÐÔÔ½À´Ô½µÍ¡£ÏÖÔÚ£¬¿¹ÌåÁìÓòµÄרÀû±£»¤Ö÷񻃾¼°ÐòÁкͰÐÔµÄÁ¬ÏµÎ»µãÁ½·½Ãæ¡£¹ØÓÚ¿¹ÌåÐòÁеÄרÀû£¬Ëü²»µ«¶ÔÕû¸öÐòö¾ÙÐб£»¤£¬Í¬Ê±Ò²»á°Ñÿһ¶ÎÐòÁж¼µ¥¶ÀÐðÊö£¬½«ÆäһЩҪº¦Á¬ÏµÎ»µã¼°Ã¿Ò»¸öСƬ¶ÏºÍÕâ¸öƬ¶ÏµÄÿһ¸öλÖÿÉÄܱ¬·¢µÄ°±»ùËá¶¼¾ÙÐб£»¤£»¶ø°ÐԵı£»¤ÔòÒ»Ñùƽ³£Í¨¹ý¶Ô°ÐÔµÄÁ¬ÏµÎ»µãºÍ¿¹ÌåµÄijÖÖÉúÎï»îÐÔµÄÏà¹ØÐÔ¾ÙÐÐÇåÎúµÄÐðÊöÀ´ÉêÇëרÀû£¬
ÈôÊÇÒ»¸ö¹«Ë¾µÄ°ÐÔλµãÒѱ»ÆäËû¹«Ë¾ÉêÇë²¢ÊÚȨ¡£ÍùÍù¾Í»áÓöµ½×¨Àû³åÍ»µÄÎÊÌâ¡£
¡ø¹ú¼Ò·Ö×Óҽѧת»¯¿ÆÑ§ÖÐÐÄ£¨Î÷°²£©-¹ú¼Ò¿¹ÌåÒ©ÎïÊÖÒÕÖÐÐÄÖ÷ÈÎ/Ê×ϯ¿ÆÑ§¼ÒÇØÃñÃñ²©Ê¿£¬ÈªÔ´£º2016Äê11ÔÂ24ÈÕ ×ðÁú¿Ê±ËÕÖÝÉúÎï´ó·Ö×ÓÒ©ÎïÑз¢Ç°ÑØÊÖÒÕ×êÑлá
ÇØÃñÃñ²©Ê¿ÌåÏÖ£¬¿¹ÌåרÀû±£»¤µÄÒªº¦µãÖ÷ÒªÕÕ¾Éfunction£¬ÈôÊÇ¿¹ÌåµÄfunctionȷʵÊÇÓÐË¢ÐµĻ°£¬¼´±ã°ÐÔÁ¬ÏµÎ»µãÏàËÆÒ²ÊÇ¿ÉÒÔ¾ÙÐÐרÀû±£»¤µÄ£¬ÈôÊÇfunctionÏàËÆ£¬°ÐÔλµãÒ²Ò»ÑùµÄ»°£¬ºÜ¿ÉÄÜÉæ¼°ÇÖȨ¡£
×ðÁú¿Ê±ËÕÖÝÉúÎï´ó·Ö×ÓÒ©ÎïÑз¢Ç°ÑØÊÖÒÕ×êÑлáÔÎÄÍøÖ·£º
http://www.medicilon.com.cn/news4/2016121413241.shtml
¿¹ÌåרÀûÍ»ÆÆ¿Ú
¾ÝϤ£¬°²½øÕë¶ÔרÀû±íλ×öÁË2¸öÐòÁп¹ÌåµÄX-ray 3DÑо¿ÒÔ¼°Éϰٸö²î±ðÐòÁп¹ÌåµÄ¾ºÕùÐÔÁ¬ÏµÊÔÑéÀ´Ö¤ÊµÕâ¸ö±íλ sweet spotµÄÌØÊâÐÔ£¬²»µÃ²»Ì¾Ï¢ÖÁ¹«Ë¾µÄÓб¸¶øÀ´¡£¿ÉÊÇÔÙÉúÔªÒ²²»ÊÇûÓзÅ̵ĿÉÄÜ£¬
ÈôÊÇÔÙÉúÔª×ö³öPraluent µÄ3D½á¹¹Äܹ»Åú×¢Ëü¸úRepathaµÄÁ¬Ïµ½Ç¶È²î±ð£¬ÄÇô¾ÍÇкÏÁ½¸ö¿¹Ìå½áÌõÔ¼Ò»¸ö±í뵫¿Õ¼ä¹¹Ïó²î±ðµÄ½áÂÛ£¬ÊÇÍêÈ«ÓпÉÄÜÅ¤×ªÊ±ÊÆµÄ¡£
3. ×ðÁú¿Ê±½á¹¹ÉúÎïѧÊÖÒÕÑо¿Ð§ÀÍÆ½Ì¨
Èô±íλµÄ±£»¤³ÉΪһÖÖ³±Á÷£¬ÄÇô¿¹ÌåÑз¢»ú¹¹½èÖú½á¹¹ÉúÎïѧÀ´±Ü¿ª±»±£»¤µÄ±íλµÄʱ´úÒ²¾Í¿ÉÒÔÔ¤¼ûÁË¡£
×ðÁú¿Ê±½á¹¹ÉúÎïѧÊÖÒÕÑо¿Ð§ÀÍÆ½Ì¨£¬×÷Ϊº£ÄÚ½ÏÔçÒ»Åú½¨ÉèµÄ»ùÓÚÂѰ×Öʾ§Ìåѧ½á¹¹µÄÐÂÒ©Ñз¢×ÛºÏЧÀÍÆ½Ì¨£¬Òѱ»ÉϺ£ÊÐÕþ¸®È϶¨ÎªÖ÷ÒªÐÂÒ©Ñз¢Æ½Ì¨¡£¸Ãƽ̨ӵÓÐ10ÓàÄêµÄ³ÉÊìÑз¢ÂÄÀú£¬Óɼ¸Ê®Î»ÂÄÀú¸»ºñµÄ´ÓÒµÖ°Ô±×é³ÉµÄÊÖÒÕÍŶӿÉÒÔÔÚ¿¹ÌåרÀû±£»¤¼°ÇÖȨ·½Ãæ×£ÄúÒ»±ÛÖ®Á¦¡£
×ðÁú¿Ê±ÉúÎﲿ¸±×ܼàÍõÌβ©Ê¿
ÍõÌβ©Ê¿ÊÇ×ðÁú¿Ê±½á¹¹ÉúÎïѧÊÖÒÕÑо¿Ð§ÀÍÆ½Ì¨µÄÖ÷ÒªÈÏÕæÈË£¬ÔøÓÚ2012ÄêÔڵ¹úÂíÆÕÉúÎïÎïÀíÑо¿ËùProf. Dr. Hartmut Michel
£¨1988ÄêµÄŵ±´¶û½±»ñµÃÕߣ©µÄʵÑéÊÒ»ñµÃÉúÎﻯѧ²©Ê¿Ñ§Î»£¬ÏÖÔÚËù×ö¿ÎÌâÉæ¼°¿ÉÈÜÐÔÂѰ×ÒÔ¼°Ä¤ÂѰס£2004-2007Äê¼ä£¬ÔÚÖйú¿ÆÑ§ÉϺ£ÉúÃü¿ÆÑ§Ñо¿Ôº¾ÙÐÐ˶ʿѧϰ£¬Ê±´ú£¬ÆÊÎöÁË2¸ö¿ÉÈÜÐÔ¹¦Ð§ÂѰ׵Ľṹ¡£Ëæºó£¬µ½µÂ¹úÂíÆÕÉúÎïÎïÀíËù´ÓÊÂĤÂѰ׹¦Ð§Óë½á¹¹µÄÑо¿£¬ÏµÍ³µØÑ§Ï°ÁËÖÖÖÖĤÂѰ׽ṹÓ빦ЧµÄÑо¿ÒªÁ첢ϲ»ñÁË2¸öĤÂѰ׾§Ì壬ÆäÖÐÒ»¸öÇø·ÖÂʵִï1.8 ?¡£2012ÄêÍõÌβ©Ê¿¼ÓÈë×ðÁú¿Ê±£¬Æù½ñΪֹ£¬Òѱí´ï´¿»¯ÁËÊý°Ù¸öÂѰף¬Íê³ÉÁ˽ü°Ù¸ö½á¹¹ÆÊÎö¡£
Dr. Tao Wang obtained his Ph.D. inbiochemistry from Max-Planck-Institute for Biophysics, Germany. The projects hejoined are from functional soluble proteins to membrane proteins. He startedhis crystallography career from 2004. From 2004 to 2007 he studied in ShanghaiInstitutes of life Science, Chinese Academy of Science. During that time, hedetermined two functional protein structures. From 2007 to 2012 He joined Prof.Dr. Hartmut Michel¡¯s lab and focused on the projects related the structure andfunction of membrane proteins. He got two membrane protein crystals and onediffracted to 1.8 ?. 2012£¬he joined in Medicilon. Untill now, he and his group purifiedhundreds of protein and solve hundred structure.
E-mail£ºtwang@medicilon.con.cn
4. ½á¹¹ÉúÎïѧЧÀÍÏà¹Ø×Éѯ£º
¡ñ¿Í·þÈÈÏߣº021-58591500ת8873
¡ñµã»÷ÎÄÄ©¡°ÔĶÁÔÎÄ¡±ÖÁ×ðÁú¿Ê±¹ÙÍø½á¹¹ÉúÎïѧЧÀÍÒ³Ãæ
5. ²Î¿¼ÎÄÕ£º
1. ÉúÎïÖÆÒ©Ð¡±à£ºÈüŵ·Æ/ÔÙÉúÔªPCSK9¿¹ÌåPraluentÃæÁÙÓÀÊÀեȡÉú²úÏúÊÛµÄÔËÆø
2. ÉúÎïÖÆÒ©Ð¡±à£º¿¹ÌåÒ©ÎïÑз¢ºÍ֪ʶ²úȨ£ºÒ»¸ö¡°¹¤½³¡±µÄ×ÔÑÔ×ÔÓï
3. W?lpl, A., et al. "Human monoclonalantibody with T©\cell©\like specificity recognizes MHC class I self©\peptidepresented by HLA©\DR1 on activated cells." Tissue antigens 51.3 (1998): 258-269.
4. »ªÈË¿¹Ìåл᣺´ÓPCSK9¿¹ÌåרÀûÖ®Õù¿´°Ðµã±íλ±£»¤